Antioxidants, Free Full-Text

Duchenne muscular dystrophy (DMD) is an X-linked recessive progressive lethal disorder caused by the lack of dystrophin, which determines myofibers mechanical instability, oxidative stress, inflammation, and susceptibility to contraction-induced injuries. Unfortunately, at present, there is no efficient therapy for DMD. Beyond several promising gene- and stem cells-based strategies under investigation, physical activity may represent a valid noninvasive therapeutic approach to slow down the progression of the pathology. However, ethical issues, the limited number of studies in humans and the lack of consistency of the investigated training interventions generate loss of consensus regarding their efficacy, leaving exercise prescription still questionable. By an accurate analysis of data about the effects of different protocol of exercise on muscles of mdx mice, the most widely-used pre-clinical model for DMD research, we found that low intensity exercise, especially in the form of low speed treadmill running, likely represents the most suitable exercise modality associated to beneficial effects on mdx muscle. This protocol of training reduces muscle oxidative stress, inflammation, and fibrosis process, and enhances muscle functionality, muscle regeneration, and hypertrophy. These conclusions can guide the design of appropriate studies on human, thereby providing new insights to translational therapeutic application of exercise to DMD patients.

Medicinal plants, antioxidant potential, and cancer - ScienceDirect

Frontiers Nitric oxide, antioxidants and prooxidants in plant defence responses, onoo 2 no2

Antioxidants, Free Full-Text, arras io 2000

Antioxidants, Free Full-Text

Antioxidants, Free Full-Text

Antioxidants, Free Full-Text

Antioxidants February 2021 - Browse Articles

Effect of alpha-lipoic acid on oxidative stress parameters: A systematic review and meta-analysis - ScienceDirect

Silica Gel: Uses and Applications – Bee Chems, Silica